PUBLICATIONS

Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development.

Dave J, Jagana V, Janostiak R, Bisserier M.

J Transl Med. 2023 Jul 17;21(1):477. doi: 10.1186/s12967-023-04339-5.

PMID: 37461108 Free PMC article. Review.

Lifetime Evaluation of Left Ventricular Structure and Function in Male C57BL/6J Mice after Gamma and Space-Type Radiation Exposure.

Brojakowska A, Jackson CJ, Bisserier M, Khlgatian MK, Grano C, Blattnig SR, Zhang S, Fish KM, Chepurko V, Chepurko E, Gillespie V, Dai Y, Lee B, Garikipati VNS, Hadri L, Kishore R, Goukassian DA.

Int J Mol Sci. 2023 Mar 13;24(6):5451. doi: 10.3390/ijms24065451.

PMID: 36982525 Free PMC article.

Author Correction: Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts.

Brojakowska A, Kour A, Thel MC, Park E, Bisserier M, Garikipati VNS, Hadri L, Mills PJ, Walsh K, Goukassian DA.

Commun Biol. 2022 Oct 10;5(1):1078. doi: 10.1038/s42003-022-04071-8.

PMID: 36217020 Free PMC article. No abstract available.

Intra-Airway Gene Delivery for Pulmonary Hypertension in Rodent Models.

Bisserier M, Boucherat O, Bonnet S, Hadri L.

Methods Mol Biol. 2022;2573:263-278. doi: 10.1007/978-1-0716-2707-5_20.

PMID: 36040601

Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts.

Brojakowska A, Kour A, Thel MC, Park E, Bisserier M, Garikipati VNS, Hadri L, Mills PJ, Walsh K, Goukassian DA.

Commun Biol. 2022 Aug 17;5(1):828. doi: 10.1038/s42003-022-03777-z.

PMID: 35978153 Free PMC article.

Spaceflight-Associated Changes of snoRNAs in Peripheral Blood Mononuclear Cells and Plasma Exosomes-A Pilot Study.

Rai AK, Rajan KS, Bisserier M, Brojakowska A, Sebastian A, Evans AC, Coleman MA, Mills PJ, Arakelyan A, Uchida S, Hadri L, Goukassian DA, Garikipati VNS.

Front Cardiovasc Med. 2022 Jun 24;9:886689. doi: 10.3389/fcvm.2022.886689. eCollection 2022.

PMID: 35811715 Free PMC article.

Astronauts Plasma-Derived Exosomes Induced Aberrant EZH2-Mediated H3K27me3 Epigenetic Regulation of the Vitamin D Receptor.

Bisserier M, Brojakowska A, Saffran N, Rai AK, Lee B, Coleman M, Sebastian A, Evans A, Mills PJ, Addya S, Arakelyan A, Garikipati VNS, Hadri L, Goukassian DA.

Front Cardiovasc Med. 2022 Jun 16;9:855181. doi: 10.3389/fcvm.2022.855181. eCollection 2022.

PMID: 35783863 Free PMC article.

Space flight associated changes in astronauts’ plasma-derived small extracellular vesicle microRNA: Biomarker identification.

Goukassian D, Arakelyan A, Brojakowska A, Bisserier M, Hakobyan S, Hadri L, Rai AK, Evans A, Sebastian A, Truongcao M, Gonzalez C, Bajpai A, Cheng Z, Dubey PK, Addya S, Mills P, Walsh K, Kishore R, Coleman M, Garikipati VNS.

Clin Transl Med. 2022 Jun;12(6):e845. doi: 10.1002/ctm2.845.

PMID: 35653543 Free PMC article. No abstract available.

Novel Insights into the Therapeutic Potential of Lung-Targeted Gene Transfer in the Most Common Respiratory Diseases.

Bisserier M, Sun XQ, Fazal S, Turnbull IC, Bonnet S, Hadri L.

Cells. 2022 Mar 12;11(6):984. doi: 10.3390/cells11060984.

PMID: 35326434 Free PMC article. Review.

Emerging Role of Exosomal Long Non-coding RNAs in Spaceflight-Associated Risks in Astronauts.

Bisserier M, Saffran N, Brojakowska A, Sebastian A, Evans AC, Coleman MA, Walsh K, Mills PJ, Garikipati VNS, Arakelyan A, Hadri L, Goukassian DA.

Front Genet. 2022 Jan 17;12:812188. doi: 10.3389/fgene.2021.812188. eCollection 2021.

PMID: 35111205 Free PMC article.

Cell-Free Mitochondrial DNA as a Potential Biomarker for Astronauts’ Health.

Bisserier M, Shanmughapriya S, Rai AK, Gonzalez C, Brojakowska A, Garikipati VNS, Madesh M, Mills PJ, Walsh K, Arakelyan A, Kishore R, Hadri L, Goukassian DA.

J Am Heart Assoc. 2021 Nov 2;10(21):e022055. doi: 10.1161/JAHA.121.022055. Epub 2021 Oct 20.

PMID: 34666498 Free PMC article.

Right predominant electrical remodeling in a pure model of pulmonary hypertension promotes reentrant arrhythmias.

Strauss B, Bisserier M, Obus E, Katz MG, Fargnoli A, Cacheux M, Akar JG, Hummel JP, Hadri L, Sassi Y, Akar FG.

Heart Rhythm. 2022 Jan;19(1):113-124. doi: 10.1016/j.hrthm.2021.09.021. Epub 2021 Sep 23.

PMID: 34563688 Free PMC article.

Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension.

Bisserier M, Katz MG, Bueno-Beti C, Brojakowska A, Zhang S, Gubara S, Kohlbrenner E, Fazal S, Fargnoli A, Dorfmuller P, Humbert M, Hata A, Goukassian DA, Sassi Y, Hadri L.

Int J Mol Sci. 2021 Aug 24;22(17):9105. doi: 10.3390/ijms22179105.

PMID: 34502015 Free PMC article.

Retrospective analysis of demographic factors in COVID-19 patients entering the Mount Sinai Health System.

Eskandari A, Brojakowska A, Bisserier M, Bander J, Garikipati VNS, Hadri L, Goukassian D, Fish K.

PLoS One. 2021 Jul 16;16(7):e0254707. doi: 10.1371/journal.pone.0254707. eCollection 2021.

PMID: 34270621 Free PMC article.

Comorbidities, sequelae, blood biomarkers and their associated clinical outcomes in the Mount Sinai Health System COVID-19 patients.

Brojakowska A, Eskandari A, Bisserier M, Bander J, Garikipati VNS, Hadri L, Goukassian DA, Fish KM.

PLoS One. 2021 Jul 6;16(7):e0253660. doi: 10.1371/journal.pone.0253660. eCollection 2021.

PMID: 34228746 Free PMC article.

Regulation of the Methylation and Expression Levels of the BMPR2 Gene by SIN3a as a Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension.

Bisserier M, Mathiyalagan P, Zhang S, Elmastour F, Dorfmüller P, Humbert M, David G, Tarzami S, Weber T, Perros F, Sassi Y, Sahoo S, Hadri L.

Circulation. 2021 Jul 6;144(1):52-73. doi: 10.1161/CIRCULATIONAHA.120.047978. Epub 2021 Jun 3.

PMID: 34078089 Free PMC article.

Molecular and Genetic Profiling for Precision Medicines in Pulmonary Arterial Hypertension.

Fazal S, Bisserier M, Hadri L.

Cells. 2021 Mar 13;10(3):638. doi: 10.3390/cells10030638.

PMID: 33805595 Free PMC article. Review.

Long-Term Effects of Very Low Dose Particle Radiation on Gene Expression in the Heart: Degenerative Disease Risks.

Garikipati VNS, Arakelyan A, Blakely EA, Chang PY, Truongcao MM, Cimini M, Malaredy V, Bajpai A, Addya S, Bisserier M, Brojakowska A, Eskandari A, Khlgatian MK, Hadri L, Fish KM, Kishore R, Goukassian DA.

Cells. 2021 Feb 13;10(2):387. doi: 10.3390/cells10020387.

PMID: 33668521 Free PMC article.

Pathophysiology and pharmacological management of pulmonary and cardiovascular features of COVID-19.

Hamouche W, Bisserier M, Brojakowska A, Eskandari A, Fish K, Goukassian DA, Hadri L.

J Mol Cell Cardiol. 2021 Apr;153:72-85. doi: 10.1016/j.yjmcc.2020.12.009. Epub 2020 Dec 26.

PMID: 33373644 Free PMC article.

Current and emerging therapeutic approaches to pulmonary hypertension.

Bisserier M, Pradhan N, Hadri L.

Rev Cardiovasc Med. 2020 Jun 30;21(2):163-179. doi: 10.31083/j.rcm.2020.02.597.

PMID: 32706206 Free PMC article. Review.

Lung-targeted SERCA2a Gene Therapy: From Discovery to Therapeutic Application in Bleomycin-Induced Pulmonary Fibrosis.

Bisserier M, Hadri L.

J Cell Immunol. 2020;2(4):149-156. Epub 2020 May 6.

PMID: 32587955 Free PMC article.

Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis.

Perdomo L, Vidal-Gómez X, Soleti R, Vergori L, Duluc L, Chwastyniak M, Bisserier M, Le Lay S, Villard A, Simard G, Meilhac O, Lezoualc’h F, Khantalin I, Veerapen R, Dubois S, Boursier J, Henni S, Gagnadoux F, Pinet F, Andriantsitohaina R, Martínez MC; Metabol study Group.

Circ Res. 2020 Aug 28;127(6):747-760. doi: 10.1161/CIRCRESAHA.120.317086. Epub 2020 Jun 16.

PMID: 32539601 Free PMC article.

Targeting epigenetic mechanisms as an emerging therapeutic strategy in pulmonary hypertension disease.

Bisserier M, Janostiak R, Lezoualc’h F, Hadri L.

Vasc Biol. 2020 Jan;2(1):R17-R34. doi: 10.1530/vb-19-0030. Epub 2020 Jan 9.

PMID: 32161845 Free PMC article.

AAV1.SERCA2a Gene Therapy Reverses Pulmonary Fibrosis by Blocking the STAT3/FOXM1 Pathway and Promoting the SNON/SKI Axis.

Bisserier M, Milara J, Abdeldjebbar Y, Gubara S, Jones C, Bueno-Beti C, Chepurko E, Kohlbrenner E, Katz MG, Tarzami S, Cortijo J, Leopold J, Hajjar RJ, Sassi Y, Hadri L.

Mol Ther. 2020 Feb 5;28(2):394-410. doi: 10.1016/j.ymthe.2019.11.027. Epub 2019 Dec 6.

PMID: 31879190 Free PMC article.

A novel secreted-cAMP pathway inhibits pulmonary hypertension via a feed-forward mechanism.

Jones C, Bisserier M, Bueno-Beti C, Bonnet G, Neves-Zaph S, Lee SY, Milara J, Dorfmüller P, Humbert M, Leopold JA, Hadri L, Hajjar RJ, Sassi Y.

Cardiovasc Res. 2020 Jul 1;116(8):1500-1513. doi: 10.1093/cvr/cvz244.

PMID: 31529026 Free PMC article.

The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats.

Katz MG, Fargnoli AS, Gubara SM, Bisserier M, Sassi Y, Bridges CR, Hajjar RJ, Hadri L.

J Vis Exp. 2019 Mar 8;(145):10.3791/59050. doi: 10.3791/59050.

PMID: 30907889 Free PMC article.

Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension.

Strauss B, Sassi Y, Bueno-Beti C, Ilkan Z, Raad N, Cacheux M, Bisserier M, Turnbull IC, Kohlbrenner E, Hajjar RJ, Hadri L, Akar FG.

J Mol Cell Cardiol. 2019 Feb;127:20-30. doi: 10.1016/j.yjmcc.2018.11.017. Epub 2018 Nov 28.

PMID: 30502350 Free PMC article.

Mechanisms of resistance to EZH2 inhibitors in diffuse large B-cell lymphomas.

Bisserier M, Wajapeyee N.

Blood. 2018 May 10;131(19):2125-2137. doi: 10.1182/blood-2017-08-804344. Epub 2018 Mar 23.

PMID: 29572378 Free PMC article.

Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death.

Fazal L, Laudette M, Paula-Gomes S, Pons S, Conte C, Tortosa F, Sicard P, Sainte-Marie Y, Bisserier M, Lairez O, Lucas A, Roy J, Ghaleh B, Fauconnier J, Mialet-Perez J, Lezoualc’h F.

Circ Res. 2017 Feb 17;120(4):645-657. doi: 10.1161/CIRCRESAHA.116.309859. Epub 2017 Jan 17.

PMID: 28096195 Free article.

Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth.

Gupta R, Forloni M, Bisserier M, Dogra SK, Yang Q, Wajapeyee N.

Elife. 2016 Sep 8;5:e16432. doi: 10.7554/eLife.16432.

PMID: 27608486 Free PMC article.

[Molecular determinants of pathological cardiac remodeling: the examples of Epac and Carabin].

Sainte-Marie Y, Bisserier M, Tortosa F, Lezoualc’h F.

Med Sci (Paris). 2015 Oct;31(10):881-8. doi: 10.1051/medsci/20153110014. Epub 2015 Oct 19.

PMID: 26481027 Free article. Review. French.

Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy.

Laurent AC, Bisserier M, Lucas A, Tortosa F, Roumieux M, De Régibus A, Swiader A, Sainte-Marie Y, Heymes C, Vindis C, Lezoualc’h F.

Cardiovasc Res. 2015 Jan 1;105(1):55-64. doi: 10.1093/cvr/cvu242. Epub 2014 Nov 19.

PMID: 25411381

Carabin protects against cardiac hypertrophy by blocking calcineurin, Ras, and Ca2+/calmodulin-dependent protein kinase II signaling.

Bisserier M, Berthouze-Duquesnes M, Breckler M, Tortosa F, Fazal L, de Régibus A, Laurent AC, Varin A, Lucas A, Branchereau M, Marck P, Schickel JN, Deloménie C, Cazorla O, Soulas-Sprauel P, Crozatier B, Morel E, Heymes C, Lezoualc’h F.

Circulation. 2015 Jan 27;131(4):390-400; discussion 400. doi: 10.1161/CIRCULATIONAHA.114.010686. Epub 2014 Nov 4.

PMID: 25369805

Epac proteins: specific ligands and role in cardiac remodelling.

Bisserier M, Blondeau JP, Lezoualc’h F.

Biochem Soc Trans. 2014 Apr;42(2):257-64. doi: 10.1042/BST20140033.

PMID: 24646227 Review.

Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.

Meloche J, Courchesne A, Barrier M, Carter S, Bisserier M, Paulin R, Lauzon-Joset JF, Breuils-Bonnet S, Tremblay É, Biardel S, Racine C, Courture C, Bonnet P, Majka SM, Deshaies Y, Picard F, Provencher S, Bonnet S.

J Am Heart Assoc. 2013 Jan 16;2(1):e005157. doi: 10.1161/JAHA.112.005157.

PMID: 23525442 Free PMC article.

Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac.

Courilleau D, Bisserier M, Jullian JC, Lucas A, Bouyssou P, Fischmeister R, Blondeau JP, Lezoualc’h F.

J Biol Chem. 2012 Dec 28;287(53):44192-202. doi: 10.1074/jbc.M112.422956. Epub 2012 Nov 8.

PMID: 23139415 Free PMC article.

Krüppel-like factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension.

Courboulin A, Tremblay VL, Barrier M, Meloche J, Jacob MH, Chapolard M, Bisserier M, Paulin R, Lambert C, Provencher S, Bonnet S.

Respir Res. 2011 Sep 27;12(1):128. doi: 10.1186/1465-9921-12-128.

PMID: 21951574 Free PMC article.

Dehydroepiandrosterone inhibits the Src/STAT3 constitutive activation in pulmonary arterial hypertension.

Paulin R, Meloche J, Jacob MH, Bisserier M, Courboulin A, Bonnet S.

Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1798-809. doi: 10.1152/ajpheart.00654.2011. Epub 2011 Sep 2.

PMID: 21890685 Free article.

RAGE-dependent activation of the oncoprotein Pim1 plays a critical role in systemic vascular remodeling processes.

Meloche J, Paulin R, Courboulin A, Lambert C, Barrier M, Bonnet P, Bisserier M, Roy M, Sussman MA, Agharazii M, Bonnet S.

Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2114-24. doi: 10.1161/ATVBAHA.111.230573. Epub 2011 Jun 16.